Modeling of glucose transport in skeletal muscle

Glucose cannot be properly regulated by insulin in type 2 diabetics. In skeletal muscle, glucose is carried into muscle mainly by glucose transporter type 4 (GLUT4), which is stimulated by insulin and exercise. This paper presents a mechanistic model of glucose transport in skeletal muscle. The mode...

Full description

Saved in:
Bibliographic Details
Main Authors: Dayu Lv, Goodwine, B
Format: Conference Proceeding
Language:English
Subjects:
glucose transport
GLUT4
metabolism modeling
Muscles
Plasmas
skeletal muscle
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glucose cannot be properly regulated by insulin in type 2 diabetics. In skeletal muscle, glucose is carried into muscle mainly by glucose transporter type 4 (GLUT4), which is stimulated by insulin and exercise. This paper presents a mechanistic model of glucose transport in skeletal muscle. The model parameters are obtained by a deterministic optimization method called DIRECT.
DOI:10.1109/BIBMW.2010.5703931