Charge sensing using point-functionalized carbonnanotube transistors for single-molecule detection

We have demonstrated that carbon-nanotube field-effect transistors act as highly sensitive single-molecule detectors when point functionalized. The hybridization kinetics of two complementary strands of DNA are associated with two-level fluctuations in the conductance of the nanotube to which the DN...

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Bibliographic Details
Main Authors: Sorgenfrei, S, Chien-Yang Chiu, Nuckolls, C, Shepard, K L
Format: Conference Proceeding
Language:English
Subjects:
carbon nanotube sensor
Carbon nanotubes
DNA
Fluctuations
Microscopy
Oxidation
Probes
single-molecule electronic detection
Transistors
Online Access:Request full text
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Summary:We have demonstrated that carbon-nanotube field-effect transistors act as highly sensitive single-molecule detectors when point functionalized. The hybridization kinetics of two complementary strands of DNA are associated with two-level fluctuations in the conductance of the nanotube to which the DNA is bound. We have studied the temperature dependence of the nanotube conductance and shown that the transport mechanism is consistent with Frenkel Poole emission, in which negatively charged DNA modulates a tunnel barrier at the point functionalized defect site. These transistors represent an important potential sensing platform for label-free single-molecule diagnostics.
DOI:10.1109/LISSA.2011.5754156