Simulation of subharmonic generation based on nonlinear oscillation from ultrasound contrast agents

In this paper, we present simulation of nonlinear oscillation motion behavior from encapsulated ultrasound contrast agents (UCAs) insonified by acoustic pressure from ultrasound wave. The backscattered signals from UCA are composed of fundamental, second harmonic, ultraharmonic and subharmonic frequ...

Full description

Saved in:
Bibliographic Details
Main Authors: Samakee, C., Phukpattaranont, P.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical imaging
Chirp
Ultrasonic imaging
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this paper, we present simulation of nonlinear oscillation motion behavior from encapsulated ultrasound contrast agents (UCAs) insonified by acoustic pressure from ultrasound wave. The backscattered signals from UCA are composed of fundamental, second harmonic, ultraharmonic and subharmonic frequencies. Especially, the subharmonic generation is specific in UCA region. Then, the subharmonic can provide higher contrast-to-tissue ratio (CTR) than the fundamental and the second harmonics. As a result, the subharmonic components can be effectively applied for medical diagnosis. In this work, we study the optimization of ultrasound parameters, i.e., the transmitted frequencies and acoustic pressures, for subharmonic generation. The results show that the subharmonic generation can be maximized using the transmitted frequencies between 1.5f r (resonant frequency) MHz and 2f r MHz, and the acoustic pressures values in the range of 0.6 to 1.2 MPa.
DOI:10.1109/ECTICON.2011.5948015