M4B: A novel method for designing and ordering of the genetic devices

In synthetic biology, designing a new genetic construct demands in-detail studies of its candidate components individually and in a composition with each other. These costly wet lab experiments require considerable amount of time and usually result in undesired output. In this paper, we propose a me...

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Bibliographic Details
Main Authors: Hashemikhabir, S., Ersoy, G., Oguz, G., Yaldiz, B., Tuncel, Y., Budak, G., Karaaslan, S., Son, Y. A., Can, T.
Format: Conference Proceeding
Language:English
Subjects:
Data mining
Genetics
Reliability
Synthetic biology
Online Access:Request full text
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Summary:In synthetic biology, designing a new genetic construct demands in-detail studies of its candidate components individually and in a composition with each other. These costly wet lab experiments require considerable amount of time and usually result in undesired output. In this paper, we propose a method for the extraction of existing or novel synthetic devices from the available biological parts or devices from iGEMs BioParts Registry and ordered the resulting devices based on their computed reliabilities. This method is very efficient and it helps the wetlab biologists in designing their genetic devices based on the given input and output in a reasonable amount of time. This method is implemented in "Mining for BioBricks" (M4B), a web-based application that facilitates the prediction of novel genetically made devices based on the given input and output.
DOI:10.1109/HIBIT.2012.6209054