In Vitro Oxygen Sensing Using Intraocular Microrobots

We present a luminescence oxygen sensor integrated with a wireless intraocular microrobot for minimally-invasive diagnosis. This microrobot can be accurately controlled in the intraocular cavity by applying magnetic fields. The microrobot consists of a magnetic body susceptible to magnetic fields an...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2012-11, Vol.59 (11), p.3104-3109
Main Authors: Ergeneman, Olgaç, Nelson, Bradley J., Chatzipirpiridis, George, Pokki, Juho, Marin-Suárez, Marta, Sotiriou, Georgios A., Medina-Rodriguez, Santiago, Sanchez, Jorge F. Fernández, Fernandez-Gutiérrez, Alberto, Pane, Salvador
Format: Article
Language:English
Subjects:
Actuation
Animals
Diagnostic Techniques, Ophthalmological - instrumentation
Eye - chemistry
Gold
Humans
Luminescence
Luminescent Measurements
magnetic
microrobots
Microtechnology - instrumentation
Models, Biological
Monitoring, Physiologic - instrumentation
nanosphere
Nanospheres
Optical sensors
Oxygen
Oxygen - analysis
photoluminescence
porphine
Robot sensing systems
Robotics - instrumentation
Signal Processing, Computer-Assisted
Wireless sensor networks
Wireless Technology - instrumentation
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a luminescence oxygen sensor integrated with a wireless intraocular microrobot for minimally-invasive diagnosis. This microrobot can be accurately controlled in the intraocular cavity by applying magnetic fields. The microrobot consists of a magnetic body susceptible to magnetic fields and a sensor coating. This coating embodies Pt(II) octaethylporphine (PtOEP) dyes as the luminescence material and polystyrene as a supporting matrix, and it can be wirelessly excited and read out by optical means. The sensor works based on quenching of luminescence in the presence of oxygen. The excitation and emission spectrum, response time, and oxygen sensitivity of the sensor were characterized using a spectrometer. A custom device was designed and built to use this sensor for intraocular measurements with the microrobot. Due to the intrinsic nature of luminescence lifetimes, a frequency-domain lifetime measurement approach was used. An alternative sensor design with increased performance was demonstrated by using poly(styrene-co-maleic anhydride) (PS-MA) and PtOEP nanospheres.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2012.2216264