Effective proliferation control of human cancer cells using electrical pulses

Since current cancer therapies do not work effectively for all patients, there is a pressing need for alternate, affordable, yet effective treatments for inoperable and chemo-resistant tumors. Presented in this paper are our investigations on the application of short duration (milli and micro second...

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Bibliographic Details
Published in:IEEE transactions on dielectrics and electrical insulation 2012-12, Vol.19 (6), p.2225-2236
Main Authors: Sundararajan, R., Funian Xiao, Salameh, T., Reece, L. M., Leary, J. F., Otto, K., Camarillo, I. G., Campana, L. G.
Format: Article
Language:English
Subjects:
Breast
Breast cancer
Cancer
Cells (biology)
DNA
Drugs
Economics
Electric potential
Electric power generation
Electroporation
flow cytometry
Human
Impedance
impedance spectroscopy
MCF-7 breast cancer cell line
Patients
proliferation control
Proteins
Voltage pulses
western blot
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Summary:Since current cancer therapies do not work effectively for all patients, there is a pressing need for alternate, affordable, yet effective treatments for inoperable and chemo-resistant tumors. Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma. For this purpose, electroporation, a pulse power technology, was evaluated for its effect upon the viability and proliferation of human breast cancer cells using a number of voltages and pulse durations. The results indicate the promising potential of electrical pulses to effectively and economically enhance drug transport across the normally impermeable plasma cell membranes and to reduce proliferation.
ISSN:1070-9878
1558-4135
DOI:10.1109/TDEI.2012.6396984