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Effective proliferation control of human cancer cells using electrical pulses

Since current cancer therapies do not work effectively for all patients, there is a pressing need for alternate, affordable, yet effective treatments for inoperable and chemo-resistant tumors. Presented in this paper are our investigations on the application of short duration (milli and micro second...

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Published in:	IEEE transactions on dielectrics and electrical insulation 2012-12, Vol.19 (6), p.2225-2236
Main Authors:	Sundararajan, R., Funian Xiao, Salameh, T., Reece, L. M., Leary, J. F., Otto, K., Camarillo, I. G., Campana, L. G.
Format:	Article
Language:	English
Subjects:	Breast Breast cancer Cancer Cells (biology) DNA Drugs Economics Electric potential Electric power generation Electroporation flow cytometry Human Impedance impedance spectroscopy MCF-7 breast cancer cell line Patients proliferation control Proteins Voltage pulses western blot
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creator	Sundararajan, R. Funian Xiao Salameh, T. Reece, L. M. Leary, J. F. Otto, K. Camarillo, I. G. Campana, L. G.
description	Since current cancer therapies do not work effectively for all patients, there is a pressing need for alternate, affordable, yet effective treatments for inoperable and chemo-resistant tumors. Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma. For this purpose, electroporation, a pulse power technology, was evaluated for its effect upon the viability and proliferation of human breast cancer cells using a number of voltages and pulse durations. The results indicate the promising potential of electrical pulses to effectively and economically enhance drug transport across the normally impermeable plasma cell membranes and to reduce proliferation.
doi_str_mv	10.1109/TDEI.2012.6396984
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subjects	Breast Breast cancer Cancer Cells (biology) DNA Drugs Economics Electric potential Electric power generation Electroporation flow cytometry Human Impedance impedance spectroscopy MCF-7 breast cancer cell line Patients proliferation control Proteins Voltage pulses western blot
title	Effective proliferation control of human cancer cells using electrical pulses
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