Spatial modeling of the Wolff-Parkinson-White syndrome induced ventricular fibrillation

Aims: The goal of this study is to assess the influence of the accessory pathway's (AcP) location and its repolarization period on the incidence of ventricular fibrillation (VF), in order to develop a non-invasive method able to select the most endangered patients that suffer from Wolff-Parkins...

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Bibliographic Details
Main Authors: Szilagyi, S. M., Szilagyi, L., Luca, C. T., Cozma, D., Ivanica, G., Enacnescu, C.
Format: Conference Proceeding
Language:English
Subjects:
Adaptation models
Atrial fibrillation
Computational modeling
Heart
Muscles
Nonhomogeneous media
Visualization
Online Access:Request full text
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Summary:Aims: The goal of this study is to assess the influence of the accessory pathway's (AcP) location and its repolarization period on the incidence of ventricular fibrillation (VF), in order to develop a non-invasive method able to select the most endangered patients that suffer from Wolff-Parkinson-White (WPW) syndrome. Methods: 12-lead ECG was recorded from 79 patients suffering from WPW (aged between 9 and 71 years) at the Cardiology Center of Timis̀§oara (Romania), and the insertion place of AcP-s were determined using Arruda localization method. We developed a spatio-temporal computerized model of the whole heart. Using a high spatio-temporal resolution we modeled the paroxysm of atrial fibrillation (AF) that in the presence of an AcP caused a catastrophically rapid ventricular response with degeneration to VF. Results: Irrespectively of the AcP location, in presence of low AcP repolarization period (under 200 ms) the VF was developed for all 79 cases (average simulation time of 2 minutes 17 seconds using five stimulations per second). Conclusion: Low repolarization period is the most important danger to VF for patients suffering from WPW, while the connection place and the location of AcP has relatively reduced imperilment impact.
ISSN:0276-6574
2325-8853