Silicon Nanotweezers with a microfluidic cavity for the real time characterization of DNA damage under therapeutic radiation beams

We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures the harsh environment of radiation beams, and still retains molecular-level detection accuracy. The real-time DNA bundle degradation is obs...

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Bibliographic Details
Main Authors: Perret, Gregoire, Po-Tsun Chiang, Lacornerie, Thomas, Kumemura, Momoko, Lafitte, Nicolas, Guillou, Herve, Jalabert, Laurent, Lartigau, Eric, Fujii, Teruo, Cleri, Fabrizio, Fujita, Hiroyuki, Collard, Dominique
Format: Conference Proceeding
Language:English
Subjects:
Cavity resonators
Degradation
DNA
Microfluidics
Radiation effects
Real-time systems
Silicon
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Summary:We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures the harsh environment of radiation beams, and still retains molecular-level detection accuracy. The real-time DNA bundle degradation is observed in terms of biomechanical stiffness and viscosity reduction, both in air and in solution. These results pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2013.6611123