Three-dimensional, automated magnetic biomanipulation with subcellular resolution

In our previous work we introduced the inverted MiniMag, a magnetic manipulation system capable of 5 degree-of-freedom (5-DOF) wireless control of micro- and nano structures. In this work, we implement a depth tracking algorithm to provide feedback on the z-position of manipulated particles in the a...

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Bibliographic Details
Main Authors: Schurle, Simone, Sakar, Mahmut Selman, Meo, Alessandro, Moller, Jens, Kratochvil, Bradley E., Chen, Christopher S., Vogel, Viola, Nelson, Bradley J.
Format: Conference Proceeding
Language:English
Subjects:
Gravity
Magnetic resonance imaging
Micromagnetics
Three-dimensional displays
Trajectory
Vectors
Online Access:Request full text
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Summary:In our previous work we introduced the inverted MiniMag, a magnetic manipulation system capable of 5 degree-of-freedom (5-DOF) wireless control of micro- and nano structures. In this work, we implement a depth tracking algorithm to provide feedback on the z-position of manipulated particles in the absence of a side camera. We demonstrate 3D closed-loop servoing of magnetic microbeads along predefined trajectories. We successfully position magnetic microbeads functionalized with antibodies in close proximity to macrophages with sub-cellular resolution and record the phagocytosis of the beads. We also show that the system can be used for 3D targeted microtissue manipulation inside microfabricated devices.
ISSN:1050-4729
2577-087X
DOI:10.1109/ICRA.2013.6630762