Clinical detection of viral infection on an optofluidic chip

We demonstrate strain-specific detection of single virus nucleic acid molecules from clinical influenza samples using an optofluidic chip. We observe a limit of detection of 10 4 virus copies/mL and 10 orders of magnitude dynamic range.

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Bibliographic Details
Main Authors: Measor, P., Zempoaltecatl, L. U., Parks, J. W., Naccache, S., Miller, S., Chiu, C. Y., Hawkins, A. R., Schmidt, H.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical optical imaging
Educational institutions
Influenza
Medical diagnostic imaging
Optical sensors
Optical waveguides
Probes
Online Access:Request full text
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Description
Summary:We demonstrate strain-specific detection of single virus nucleic acid molecules from clinical influenza samples using an optofluidic chip. We observe a limit of detection of 10 4 virus copies/mL and 10 orders of magnitude dynamic range.
ISSN:2160-8989
2160-9004
DOI:10.1364/CLEO_SI.2013.CM1M.7