Pulmonary blood flow analysis based on two input model with aorta and pulmonary artery contribution using contrast-enhanced MRI

A new pulmonary blood flow analysis is proposed. It uses a two-input model to include the recirculation from the aorta into the lung. The impulse response from each input (pulmonary artery route and recirculated aorta route) is assumed to be a gamma variate model. The effect of each input is separat...

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Bibliographic Details
Main Authors: Ichikawa, M., Gotoh, T., Kagei, S., Iwasawa, T., Tsuzuki, M. S. G.
Format: Conference Proceeding
Language:English
Subjects:
Analytical models
Arteries
Biomedical imaging
Blood
Blood flow
blood volume
Cancer
DSC-MRI
gama variate model
Gd contrast agent
Lungs
Tumors
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Description
Summary:A new pulmonary blood flow analysis is proposed. It uses a two-input model to include the recirculation from the aorta into the lung. The impulse response from each input (pulmonary artery route and recirculated aorta route) is assumed to be a gamma variate model. The effect of each input is separately analyzed. Based on that, a method to determine the blood flow, blood volume and mean transit time is proposed. The method proposed is tested with MR contrast-enhanced images obtained from patients with lung cancer. It is shown that the recirculated blood flow can not be ignored for patients with lung cancer and without the lung arteries.
ISSN:1945-7928
1945-8452
DOI:10.1109/ISBI.2014.6868012