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Functional validation of an implantable medical dosing device by MRI at 3T

Sustained release of a small molecule from a prototype implantable drug delivery device was monitored via MRI in an ex vivo tissue phantom over a period of two days. T1 mapping was used as a method to quantify analyte concentration. Continuous, controlled release was observed. The MRI methodology wa...

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Bibliographic Details
Main Authors: Anderson, Jeff R., Ferrati, Silvia, Karmonik, Chistof, Grattoni, Alessandro
Format: Conference Proceeding
Language:English
Subjects:
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Description
Summary:Sustained release of a small molecule from a prototype implantable drug delivery device was monitored via MRI in an ex vivo tissue phantom over a period of two days. T1 mapping was used as a method to quantify analyte concentration. Continuous, controlled release was observed. The MRI methodology was thus found to be appropriate for device validation and quality assurance/control.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2014.6944091