Non-invasive method to detect the changes of glucose concentration in whole blood using photometric technique

A non-invasive method is developed to monitor rapid changes in blood glucose levels in diabetic patients. The system depends on an optical cell built with a LED that emits light of wavelength 535nm, which is a peak absorbance of hemoglobin. As the glucose concentration in blood decreases, its osmola...

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Bibliographic Details
Published in:2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2014-01, Vol.2014, p.4034-4037
Main Authors: Rajan, Shiny Amala Priya, Towe, Bruce C.
Format: Article
Language:English
Subjects:
Blood
Electron tubes
Light emitting diodes
Monitoring
Optical sensors
Optical variables control
Sugar
Online Access:Request full text
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Summary:A non-invasive method is developed to monitor rapid changes in blood glucose levels in diabetic patients. The system depends on an optical cell built with a LED that emits light of wavelength 535nm, which is a peak absorbance of hemoglobin. As the glucose concentration in blood decreases, its osmolarity also decreases and the Red Blood Cells (RBCs) swell and decrease the path length absorption coefficient. Decreasing absorption coefficient increases the transmission of light through the whole blood. The system was tested with a constructed optical cell that held whole blood in a capillary tube. As expected the light transmitted to the photodiode increases with decreasing glucose concentration. The average response time of the system was between 30-40 seconds.
ISSN:1094-687X
1558-4615
2694-0604
DOI:10.1109/EMBC.2014.6944509