Measurements and calculations of protein intramolecular vibrations in the THz range

We report the calculations and measurements of intramolecular vibrational modes and their dependence on inhibitor binding in the THz range. We see an increase in anisotropic THz absorption at low frequency with inhibitor binding in both the measurements and calculations. This surprising result sugge...

Full description

Saved in:
Bibliographic Details
Main Authors: Niessen, Katherine A., Snell, Edward, Markelz, A. G.
Format: Conference Proceeding
Language:English
Subjects:
Absorption
Crystals
Frequency measurement
Inhibitors
Proteins
Temperature measurement
Vibration measurement
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the calculations and measurements of intramolecular vibrational modes and their dependence on inhibitor binding in the THz range. We see an increase in anisotropic THz absorption at low frequency with inhibitor binding in both the measurements and calculations. This surprising result suggests an increase in flexibility with binding. We will discuss the possible reasons for this discrepancy.
ISSN:2162-2027
DOI:10.1109/IRMMW-THz.2014.6956080