Disposable point-of-use optical biosensor for multiple biomarker detection

This work explored the viability of a new miniaturized fluorescence measurement-based sensor architecture using organic light emitting diode (OLED) display and photodiode active matrix array technology for point-of-use diagnosis of multiple disease biomarkers in a low cost disposable configuration....

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Bibliographic Details
Main Authors: Smith, Joseph T., Katchman, Benjamin A., Yong-Kyun Lee, O'Brien, Barry P., Bawolek, Edward J., Shah, Sahil S., Christen, Jennifer Blain
Format: Conference Proceeding
Language:English
Subjects:
active matrix array
Arrays
Biomarker
Biomedical optical imaging
biosensor
Fluorescence
OLED
Optical filters
Optical polarization
Optical sensors
Organic light emitting diodes
photodiode
point-of-care
TFT
Thin-film transistor
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Description
Summary:This work explored the viability of a new miniaturized fluorescence measurement-based sensor architecture using organic light emitting diode (OLED) display and photodiode active matrix array technology for point-of-use diagnosis of multiple disease biomarkers in a low cost disposable configuration. Sensor feasibility and optical performance were evaluated using a bright 0.3mW/mm 2 2 × 2 mm, 455nm blue OLED emitter test structure configured first with orthogonally crossed linear polarizing film; and second, with band-pass and long-pass optical filters. Preliminary measurement results indicated that this type of sensor architecture requires optical filters to approach the sensitivity of laboratory fluorescence-based instrumentation.
ISSN:2163-4025
2766-4465
DOI:10.1109/BioCAS.2014.6981714