Parameter estimation of pharmacokinetics models in the presence of timing noise

The problem addressed in this paper deals with the parameter estimation of in vitro uptake kinetics of drugs into living cells in presence of timing noise. Effects of the timing noise on the bias and variance of the output error are explicitly determined. A bounded-error parameter estimation approac...

Full description

Saved in:
Bibliographic Details
Main Authors: Bastogne, Thierry, Mezieres-Wantz, Sophie, Ramdani, Nacim, Vallois, Pierre, Barberi-Heyob, Muriel
Format: Conference Proceeding
Language:English
Subjects:
biological systems
bounded errors
Drugs
Errors
Handles
In vitro
Kinetic theory
Mathematical models
Noise
Parameter estimation
pharmacokinetics models
Time measurements
Timing
timing errors
Uptakes
Variance
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The problem addressed in this paper deals with the parameter estimation of in vitro uptake kinetics of drugs into living cells in presence of timing noise. Effects of the timing noise on the bias and variance of the output error are explicitly determined. A bounded-error parameter estimation approach is proposed as a suited solution to handle this problem. Application results are presented and emphasize its effectiveness in such an experimental framework.
DOI:10.23919/ECC.2007.7068380