Early detection of bronchiolitis obliterans syndrome in lung transplant recipients with chronic rejection using home spirometry

Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for...

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Bibliographic Details
Main Authors: Finkelstein, S.M., Hertz, M.I., Snyder, M., Stibbe, C.E., Sabati, N., Lindgren, B., Dutta, P., Killoren, T., Slagle, J.
Format: Conference Proceeding
Language:English
Subjects:
Cardiac disease
Cardiovascular diseases
Instruments
Lungs
Monitoring
Protocols
Pulse measurements
Samarium
Testing
USA Councils
Online Access:Request full text
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Summary:Declining pulmonary function, as measured by staging for bronchiolitis obliterans syndrome, is considered primary indication of future chronic rejection in transplanted lungs. Staging has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Eleven of 104 lung recipients were diagnosed with chronic rejection. Seven of these subjects had performed home monitoring for a minimum of 8 months at the time of this study. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Using home spirometry, the onset of decline began an average of 284 days before diagnosis of chronic rejection, which was significantly earlier (p
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.1997.756533