Effect of fluid viscosity and erythrocytes on monocyte adhesion

Monocyte recruitment to vascular endothelium is a key event linked to the development of atherosclerosis. Adhesion is influenced by many parameters including local fluid dynamics, intracellular collisions, and adhesion receptor expression. Elevated medium viscosity as well as the presence of erythro...

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Bibliographic Details
Main Authors: Rinker, K.D., Prabhakar, V., Osborn, E.A., Truskey, G.A.
Format: Conference Proceeding
Language:English
Subjects:
Adhesion
Adhesives
Biomedical engineering
Cell culture
Cells
Cells (biology)
Fluid dynamics
Frequency
Hemodynamics
Humans
Recruitment
Red blood cells
Shear flow
Stress
Viscosity
Viscosity of liquids
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Summary:Monocyte recruitment to vascular endothelium is a key event linked to the development of atherosclerosis. Adhesion is influenced by many parameters including local fluid dynamics, intracellular collisions, and adhesion receptor expression. Elevated medium viscosity as well as the presence of erythrocytes in monocyte-containing media was found to increase monocyte adhesion to vascular endothelial cells. By comparing monocyte rolling velocities and arrest durations in fluids of differing viscosities at the same shear rates, monocyte adhesion was found to be shear stress dependent. Supplementation of the monocyte-containing medium with red blood cells increased tethering frequencies to a greater extent than the effect of elevated viscosity alone.
ISSN:1094-687X
0589-1019
1558-4615
DOI:10.1109/IEMBS.1999.802085