Model-augmented investigations on field-stimulated cardiomyocytes

An experimental and theoretical approach was used to reveal and explain particular complex behavior of cardiac cells under electric field stimuli. The use of straightforward modeling forms a strong alliance with the optical recording technique to adequately explain the underlying mechanisms. Optical...

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Bibliographic Details
Main Authors: Platzer, D., Dapra, D., Gunter, C., Windisch, H.
Format: Conference Proceeding
Language:English
Subjects:
Bioelectric phenomena
Biomedical optical imaging
Biomembranes
Cardiology
Cell membranes
Electric currents
Electric shock
Electrophysiology
Fluorescence
Ionic conduction
Kinetic theory
Mathematical models
Muscle
Optical pulses
Optical recording
Optical sensors
Pulse measurements
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Summary:An experimental and theoretical approach was used to reveal and explain particular complex behavior of cardiac cells under electric field stimuli. The use of straightforward modeling forms a strong alliance with the optical recording technique to adequately explain the underlying mechanisms. Optical recordings reveal behavior that can not be explained by membrane kinetic descriptions established under physiological conditions and lead to an augmented ionic current model for the cardiac ventricular cells under investigation.
ISSN:1094-687X
0589-1019
1558-4615
DOI:10.1109/IEMBS.1999.802182