Reconstruction of myocardial architecture at high resolution using diffusion tensor MRI

Diffusion tensor MRI (DTMRI) is a possible new means of elucidating the anatomic structure of the myocardium. It enjoys several advantages over traditional histological methods, including its ability to rapidly and nondestructively measure fiber architecture at very high resolution. However, quantit...

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Bibliographic Details
Main Authors: Scollan, D.F., Holmes, A.A., Jianyang Zhang, Winslow, R.L.
Format: Conference Proceeding
Language:English
Subjects:
Biomedical imaging
Computer architecture
Computer simulation
Geometry
Heart
High-resolution imaging
Image reconstruction
Magnetic resonance imaging
Myocardium
Optical resolving power
Rabbits
Tensile stress
Tensors
Visualization
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Description
Summary:Diffusion tensor MRI (DTMRI) is a possible new means of elucidating the anatomic structure of the myocardium. It enjoys several advantages over traditional histological methods, including its ability to rapidly and nondestructively measure fiber architecture at very high resolution. However, quantitative validation of this MRI method has been lacking. Here, fiber orientations are estimated at the same locations using both DTMRI and histology in one formalin-fixed rabbit heart. Fiber orientations were statistically similar, differing on average by 5.3/spl deg/ (RMS) at any one location. The ventricular myofiber architecture of a number of normal rabbit hearts was then reconstructed using DTMRI into 3-D computer models for visualization. Myofiber organization appeared qualitatively similar to a previous high-resolution reconstruction using traditional histology.
ISSN:1094-687X
0589-1019
1558-4615
DOI:10.1109/IEMBS.1999.804230