Sensing Characteristic of Arrayed Flexible Indium Gallium Zinc Oxide Lactate Biosensor Modified by GO and Magnetic Beads

In this study, the arrayed flexible indium gallium zinc oxide (IGZO) lactate biosensor was modified by graphene oxide (GO) and magnetic beads (MB). The biosensor has arrayed structure with six sensing windows. The arrayed structure with six IGZO windows was fabricated by using radio frequency sputte...

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Bibliographic Details
Published in:IEEE transactions on nanotechnology 2018-01, Vol.17 (1), p.147-153
Main Authors: Chou, Jung-Chuan, Chen, Hsiang-Yi, Liao, Yi-Hung, Lai, Chih-Hsien, Yan, Siao-Jie, Wu, Cian-Yi, Wu, You-Xiang
Format: Article
Language:English
Subjects:
Beads
Biochemistry
Biosensors
Detection
Electrochemical impedance spectroscopy
Electrodes
Flow velocity
Gallium
Graphene oxide
Indium
Indium gallium zinc oxide
Indium gallium zinc oxide (IGZO)
Magnetic bead
Microfluidic device
Microfluidics
Sensitivity
Sensitivity enhancement
Voltage measurement
Zinc oxides
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Summary:In this study, the arrayed flexible indium gallium zinc oxide (IGZO) lactate biosensor was modified by graphene oxide (GO) and magnetic beads (MB). The biosensor has arrayed structure with six sensing windows. The arrayed structure with six IGZO windows was fabricated by using radio frequency sputtering system and screen-printed technology. The lactate enzyme was combined with GO and MB, and which was immobilized on the IGZO windows by the crossing-link method. The GO and MB could enhance the average sensitivity of the lactate biosensor, and the optimal content was also investigated. After that, the lactate biosensor was integrated in the microfluidic device, and the average sensitivity also could be enhanced by controlling the flow rate of test solution. Furthermore, the electrochemical reaction of different sensing films could be described by electrochemical impedance spectroscopy.
ISSN:1536-125X
1941-0085
DOI:10.1109/TNANO.2017.2782756