Differential method for undisturbed detection of 17β-estradiol using an integrated aptameric graphene nanosensor

This paper presents a differential method based on the graphene field effect biosensor for the rapid and specific quantification of environmental pollution-related biochemical analyte. Selectively functionalizing one of the two identical graphene channels and calibrating the sensitivity difference o...

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Bibliographic Details
Main Authors: Li, Yijun, Zhu, Yibo, Hao, Zhuang, Wang, Cheng, Zhang, Zhixing, He, Miao, Lin, Qiao
Format: Conference Proceeding
Language:English
Subjects:
Biosensors
Field effect transistors
Graphene
Microfluidics
Sensitivity
Testing
Transconductance
Online Access:Request full text
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Summary:This paper presents a differential method based on the graphene field effect biosensor for the rapid and specific quantification of environmental pollution-related biochemical analyte. Selectively functionalizing one of the two identical graphene channels and calibrating the sensitivity difference of the two channels allowed us to extract analyte binding-induced signals by subtracting irregular and unpredictable background. Using this method we demonstrated real-time monitoring of 17β-estradiol in electrolytes with varying pH value. This work represents important progress of graphene field effect sensors toward use with complex real samples.
ISSN:2160-1968
DOI:10.1109/MEMSYS.2018.8346543