CMOS High-Voltage Analog 1-64 Multiplexer/Demultiplexer for Integrated Ultrasound Guided Breast Needle Biopsy

• Published in: IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2018-08, Vol.65 (8), p.1334-1345
• Main Authors: Jung, Hayong, Wodnicki, Robert, Lim, Hae Gyun, Yoon, Chi Woo, Kang, Bong Jin, Yoon, Changhan, Lee, Changyang, Hwang, Jae Youn, Kim, Hyung Ham, Choi, Hojong, Chen, Mike Shuo-Wei, Zhou, Qifa, Shung, K. Kirk
• Format: Article
• Language: English
• Subjects: Aperture imaging; Apertures; Biopsy; Biopsy needle; Breast; breast cancer; CMOS; high frequency; High voltages; high-voltage switch; High-voltage techniques; Imaging; Insertion loss; Integrated circuits; Low voltage; Multiplexing; Needles; Switches; synthetic aperture imaging; Ultrasonic imaging; ultrasound
• ISSN: 0885-3010; 1525-8955
• DOI: 10.1109/TUFFC.2018.2837127

Ultrasound guided needle biopsy is an important method for collection of breast cancer tissue. In this paper, we report on the design and testing of a high-voltage 1 to 64 Multiplexer/Demultiplexer (MUX/De-MUX) integrated circuit (IC) for ultrasound-guided breast biopsy applications implemented in a high-voltage CMOS process. The IC is intended to be incorporated inside the breast biopsy needle and is designed to fit inside the needle inner diameter of 2.38 mm. The MUX/De-MUX electronics are made up of three parts, including a low-voltage 6 to 64 decoder, a level shifter to convert from low voltage to high voltage, and analog high-voltage switches. Experimental results show a -3-dB bandwidth of over 70 MHz, Rds (on) of 140 Ω, -2.279-dB insertion loss, and -17.5-dB off isolation at 70 MHz with low-voltage input. Finally, we present results obtained via synthetic aperture imaging using the fabricated MUX/De-Mux device and a high-frequency ultrasound array. This device and technique hold promise for high-frequency imaging probes where a limited number of elements are used and the depth of penetration is short such as in breast biopsy and intravascular applications.