Ultrasound Localization Microscopy and Super-Resolution: A State of the Art

Because it drives the compromise between resolution and penetration, the diffraction limit has long represented an unreachable summit to conquer in ultrasound imaging. Within a few years after the introduction of optical localization microscopy, we proposed its acoustic alter ego that exploits the m...

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Published in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2018-08, Vol.65 (8), p.1304-1320
Main Authors: Couture, Olivier, Hingot, Vincent, Heiles, Baptiste, Muleki-Seya, Pauline, Tanter, Mickael
Format: Article
Language:English
Subjects:
Acoustic microscopy
Acoustics
Angiography
Arteriosclerosis
Bioengineering
Biotechnology
Blood vessels
Brain
Contrast agents
Diabetes mellitus
Engineering Sciences
Imaging
Life Sciences
Localization
microbubbles
Microscopy
Optical diffraction
Spatial resolution
super-resolution
Ultrasonic imaging
ultrasound localization microscopy (ULM)
Velocimetry
Velocity measurement
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Summary:Because it drives the compromise between resolution and penetration, the diffraction limit has long represented an unreachable summit to conquer in ultrasound imaging. Within a few years after the introduction of optical localization microscopy, we proposed its acoustic alter ego that exploits the micrometric localization of microbubble contrast agents to reconstruct the finest vessels in the body in-depth. Various groups now working on the subject are optimizing the localization precision, microbubble separation, acquisition time, tracking, and velocimetry to improve the capacity of ultrasound localization microscopy (ULM) to detect and distinguish vessels much smaller than the wavelength. It has since been used in vivo in the brain, the kidney, and tumors. In the clinic, ULM is bound to improve drastically our vision of the microvasculature, which could revolutionize the diagnosis of cancer, arteriosclerosis, stroke, and diabetes.
ISSN:0885-3010
1525-8955
DOI:10.1109/TUFFC.2018.2850811