Application of a Microfluidic-Based Model of a Human Prostate Gland for Cancer Research

A Microfluidic-based model of a human prostate gland has been developed featuring a 3D co-culture of epithelial and stromal cells. The model was used to investigate the effects of normal stroma on normal luminal epithelial cell differentiation, and to measure the ability of cancerous epithelium to c...

Full description

Saved in:
Bibliographic Details
Main Authors: Ivich, Fernando, Tran, Meagan, Tahsin, Shekha, Frank, Sander B., Kraft, Andrew, Miranti, Cindy K., Zohar, Yitshak, Jiang, Linan
Format: Conference Proceeding
Language:English
Subjects:
Biomembranes
epithelium/stroma coculture
Glands
human prostate gland
Microchannels
Microfluidics
Prostate cancer
Tumors
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A Microfluidic-based model of a human prostate gland has been developed featuring a 3D co-culture of epithelial and stromal cells. The model was used to investigate the effects of normal stroma on normal luminal epithelial cell differentiation, and to measure the ability of cancerous epithelium to convert normal stroma to cancer stroma. The ability of PIM1 kinase to induce cancer stroma was also tested in the model. The results demonstrate a promising potential of the model for cancer research applications.
ISSN:2159-6972
DOI:10.1109/NANOMED.2018.8641586