22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, no...

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Bibliographic Details
Main Authors: Pazhouhandeh, M. Reza, OrLeary, Gerard, Weisspapir, Iliya, Groppe, David, Nguyen, Xuan-Thuan, Abdelhalim, Karim, Jafari, Hamed Mazhab, Valiante, Taufik A., Carlen, Peter, Verma, Naveen, Genov, Roman
Format: Conference Proceeding
Language:English
Subjects:
Computer architecture
Electrodes
Electroencephalography
Impedance
Monitoring
Neuromodulation
Sleep
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Summary:An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.
ISSN:2376-8606
DOI:10.1109/ISSCC.2019.8662458