Mechano-Chemical Interactions in Cardiac Sarcomere Shortening

Tension development in the cardiac sarcomere is highly cooperative, yet the mechanism is not known. We have developed the MechChem model of sarcomere mechanics, which incorporates a mechano-chemical interaction-based cooperativity mechanism in which the thin filament has an intrinsic chemical cooper...

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Bibliographic Details
Main Authors: Dupuis, Lauren J, Lumens, Joost, Arts, Theo, Delhaas, Tammo
Format: Conference Proceeding
Language:English
Subjects:
Calcium
Data models
Force
Heart
Manganese
Mathematical model
Muscles
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Summary:Tension development in the cardiac sarcomere is highly cooperative, yet the mechanism is not known. We have developed the MechChem model of sarcomere mechanics, which incorporates a mechano-chemical interaction-based cooperativity mechanism in which the thin filament has an intrinsic chemical cooperativity that is boosted by mechanical tension in the thin filament. In the current study, we extend the MechChem model to include the possibility for the sarcomere to change length when contracting against different afterloads. The model was tested at various afterloads and compared to experimental data. The MechChem model successfully reproduced isotonic twitch experiments.
ISSN:2325-887X
DOI:10.22489/CinC.2018.274