A Multi-Scale Investigation of Global Electrical Heterogeneity: Effects of Body Habitus, Respiration, and Tissue Conductivity

Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD...

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Bibliographic Details
Main Authors: Perez-Alday, Erick A, Ni, Haibo, Hamilton, Christopher, Li-Pershing, Annabel, Jaar, Bernard, Monroy-Trujillo, Jose M, Estrella, Michelle, Parekh, Rulan, Zhang, Henggui, Tereshchenko, Larisa
Format: Conference Proceeding
Language:English
Subjects:
Computational modeling
Conductivity
Data models
Electrocardiography
Heart
Lung
Torso
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Summary:Extracardiac factors such as respiration, fluid overload and body habitus have important effects on the ECG voltage. Vectorcardiographic (VCG) Global Electrical Heterogeneity (GEH) is associated with sudden cardiac death (SCD). Risk of SCD is especially high in end-stage renal disease patients (ESRD) on dialysis. However, extracardiac factors challenge ECG interpretation in ESRD patients. The effects of extracardiac factors on GEH have not been fully studied. To assess effects of extracardiac factors on ECG, we conducted a multi-scale study. An experimental data of ESRD patients and a previously developed biophysically detailed heart-torso model were used to investigate the effects of respiration, fluid overload and body habitus on the VCG and GEH.
ISSN:2325-8861
2325-887X
DOI:10.22489/CinC.2018.161