Temporal Modulation of the Response of Sensory Fibers to Paired-Pulse Stimulation

Multi-channel nerve cuff electrode arrays can provide sensory feedback to prosthesis users. To develop efficacious stimulation protocols, an understanding of the impact that spatio-temporal patterned stimulation can have on the response of sensory fibers is crucial. We used experimental and modellin...

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Bibliographic Details
Published in:IEEE transactions on neural systems and rehabilitation engineering 2019-09, Vol.27 (9), p.1676-1683
Main Authors: Brunton, Emma K., Silveira, Carolina, Rosenberg, Joshua, Schiefer, Matthew A., Riddell, John, Nazarpour, Kianoush
Format: Article
Language:English
Subjects:
Action potentials
Action Potentials - physiology
Animals
Computer Simulation
Dorsal roots
Electric Stimulation
Electrodes
Electrodes, Implanted
Feedback, Sensory
Fibers
in vivo
Microelectrodes
Modelling
Models, Neurological
Nerve Fibers
Nerves
neural engineering
Paired-pulse stimulation
Prostheses
Prosthesis Design - methods
Prosthetics
Rats
Rats, Sprague-Dawley
Sciatic nerve
Sciatic Nerve - physiology
Sensor arrays
sensory aids
Sensory feedback
Sensory neurons
Sensory Receptor Cells - physiology
Skin
Stimulation
Stimuli
Tungsten
Wires
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Summary:Multi-channel nerve cuff electrode arrays can provide sensory feedback to prosthesis users. To develop efficacious stimulation protocols, an understanding of the impact that spatio-temporal patterned stimulation can have on the response of sensory fibers is crucial. We used experimental and modelling methods to investigate the response of nerve fibers to paired-pulse stimulation. Nerve cuff electrode arrays were implanted for stimulation of the sciatic nerves of rats and the sensory compound action potentials were recorded from the L4 dorsal root. A model of the nerve cuff electrode array and sciatic nerve was also developed. The experimental and modelling results were compared. Experiments showed that it took 8 ms for the sensory fibers to completely recover from a conditioning stimulus, regardless of the relative position of the electrodes used for stimulation. The results demonstrate that the electrodes on the cuff cannot be considered independent. Additionally, at 120% of the threshold, there is a large overlap in the fibers that were activated by the different electrodes. If a stimulus paradigm considered the electrodes as independent, stimuli from the different electrodes would need to be interleaved, and the intervals between the stimuli should be greater than 8 ms.
ISSN:1534-4320
1558-0210
DOI:10.1109/TNSRE.2019.2935813