PLGA Encapsulated Methylene Blue as a Contrast Agent for Optical Coherence Tomography

Methylene Blue (MB), an FDA approved dye, has been widely used in clinical applications. However, issues remain for its use as contrast agent: production of 1O2, reduction into leuco-MB, and nonspecific tagging. These issues were addressed by loading MB into Poly-Lactic-co-Glycolic Acid (PLGA) parti...

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Bibliographic Details
Main Authors: Palma, J. A., Kim, W., Serafino, M., Kim, S., Jo, J. A., Charoenphol, P., Applegate, B. E.
Format: Conference Proceeding
Language:English
Subjects:
Absorption
Nanoparticles
Optical coherence tomography
Production
Stationary state
Tagging
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Description
Summary:Methylene Blue (MB), an FDA approved dye, has been widely used in clinical applications. However, issues remain for its use as contrast agent: production of 1O2, reduction into leuco-MB, and nonspecific tagging. These issues were addressed by loading MB into Poly-Lactic-co-Glycolic Acid (PLGA) particles.
ISSN:2575-274X
DOI:10.1109/IPCon.2019.8908365