Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2

• Published in: IEEE sensors journal 2020-04, Vol.20 (8), p.4251-4259
• Main Authors: Sharma, Sonika, Shrivastav, Anand M., Gupta, Banshi D.
• Format: Article
• Language: English
• Subjects: Antibodies; Aqueous solutions; Biomarkers; Biomedical materials; Creatinine; Fiber optics; Imprinted polymers; lossy mode resonance; Molecular imprinting; Molybdenum disulfide; molybdenum sulphide; Muscles; Nanocomposites; Optical device fabrication; optical fiber sensor; Optical fiber sensors; Optical fibers; Optical losses; Polymer films; Polymers; Probes; Resonance; Selectivity; Sensors; Tin dioxide; tin oxide; Urine
• ISSN: 1530-437X; 1558-1748
• DOI: 10.1109/JSEN.2020.2964262

Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS 2 @SnO 2 nanocomposite as LMR supporting material and MoS 2 @SnO 2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.