The effect of interburst intervals on measures of hippocampal LTP in the freely moving adult male rat

An important factor in the induction and maintenance of long-term potentiation (LTP) is the tetanization paradigm. This paper presents the changes associated with the induction and maintenance of hippocampal LTP in the freely moving adult male rat, subjected to three different tetanization paradigms...

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Bibliographic Details
Main Authors: Fortin, D.A., Bronzino, J.D.
Format: Conference Proceeding
Language:English
Subjects:
Anesthesia
Animals
Bones
Educational institutions
Electrodes
Frequency
Position measurement
Pulse measurements
Rats
Space vector pulse width modulation
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Summary:An important factor in the induction and maintenance of long-term potentiation (LTP) is the tetanization paradigm. This paper presents the changes associated with the induction and maintenance of hippocampal LTP in the freely moving adult male rat, subjected to three different tetanization paradigms. These results indicate that specific LTP measures including, synaptic activation, as measured by the slope of the dentate granule cell population excitatory post synaptic potential (EPSP) and the cellular response, as measured by the dentate population spike amplitude (PSA), evoked by single pulse stimulation of the medial perforant pathway are dependent on the bursting paradigm used in chronic recording studies in freely moving animals.
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.2000.900721