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MoS2 Functionalized Multicore Fiber Probes for Selective Detection of Shigella Bacteria Based on Localized Plasmon

Present study demonstrates the fiber-optic localized surface plasmon resonance (LSPR) based sensitive biosensor for detection of Shigella bacterial species. The proposed sensor is comprised of multi-core fiber (MCF) having seven cores arranged in a hexagonal shape and spliced with single-mode fiber...

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Bibliographic Details
Published in:Journal of lightwave technology 2021-06, Vol.39 (12), p.4069-4081
Main Authors: Kumar, Santosh, Guo, Zhu, Singh, Ragini, Wang, Qinglin, Zhang, Bingyuan, Cheng, Shuang, Liu, Feng-Zhen, Marques, Carlos, Kaushik, Brajesh Kumar, Jha, Rajan
Format: Article
Language:English
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Summary:Present study demonstrates the fiber-optic localized surface plasmon resonance (LSPR) based sensitive biosensor for detection of Shigella bacterial species. The proposed sensor is comprised of multi-core fiber (MCF) having seven cores arranged in a hexagonal shape and spliced with single-mode fiber (SMF) for efficient detection. An increase in evanescent waves (EWs) and coupling of modes between MCF cores was achieved by etching process in a controlled manner. The etching process also increases the refractive index sensitivity (RIS) of the proposed sensor. Further, coating with nanomaterials like gold nanoparticles (AuNPs) and molybdenum disulfide (MoS 2 ) helps in the excitation of localized plasmons. Here, Shigella specific oligonucleotide probes are used as a recognition element. The results demonstrate that the proposed sensor can successfully and efficiently detect the Shigella bacterial species with high sensitivity. Shigella in the range of 10 - 100 CFU/mL (colony-forming unit/mL) can cause serious intestinal infection and therefore, its detection in this range is critical. The proposed sensor demonstrates a linearity range from 1 to 10 9  CFU/mL with a detection time of 5 min and a limit of detection (LoD) of 1.56 CFU/mL. The proposed sensing methodology can be a potential alternative to the commercially existing ones in the near future.
ISSN:0733-8724
1558-2213
DOI:10.1109/JLT.2020.3036610