MoS2 Functionalized Multicore Fiber Probes for Selective Detection of Shigella Bacteria Based on Localized Plasmon

• Published in: Journal of lightwave technology 2021-06, Vol.39 (12), p.4069-4081
• Main Authors: Kumar, Santosh, Guo, Zhu, Singh, Ragini, Wang, Qinglin, Zhang, Bingyuan, Cheng, Shuang, Liu, Feng-Zhen, Marques, Carlos, Kaushik, Brajesh Kumar, Jha, Rajan
• Format: Article
• Language: English
• Subjects: <named-content xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" content-type="math" xlink:type="simple"> <inline-formula> <tex-math notation="LaTeX"> Shigella</tex-math> </inline-formula> </named-content>; Bacteria; Biosensors; Etching; Evanescent waves; Fiber optics; Gold; Gold nanoparticles (AuNPs); localized surface plasmon resonance; Microorganisms; Molybdenum disulfide; molybdenum disulfide (MoS<named-content xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" content-type="math" xlink:type="simple"> <inline-formula> <tex-math notation="LaTeX"> _2</tex-math> </inline-formula> </named-content>); multicore fiber; Multicore processing; Nanomaterials; Nanoparticles; optical fiber biosensor; Optical fiber sensors; Optical fibers; Plasmons; Probes; Refractivity; Sensitivity; Sensors
• ISSN: 0733-8724; 1558-2213
• DOI: 10.1109/JLT.2020.3036610

Present study demonstrates the fiber-optic localized surface plasmon resonance (LSPR) based sensitive biosensor for detection of Shigella bacterial species. The proposed sensor is comprised of multi-core fiber (MCF) having seven cores arranged in a hexagonal shape and spliced with single-mode fiber (SMF) for efficient detection. An increase in evanescent waves (EWs) and coupling of modes between MCF cores was achieved by etching process in a controlled manner. The etching process also increases the refractive index sensitivity (RIS) of the proposed sensor. Further, coating with nanomaterials like gold nanoparticles (AuNPs) and molybdenum disulfide (MoS 2 ) helps in the excitation of localized plasmons. Here, Shigella specific oligonucleotide probes are used as a recognition element. The results demonstrate that the proposed sensor can successfully and efficiently detect the Shigella bacterial species with high sensitivity. Shigella in the range of 10 - 100 CFU/mL (colony-forming unit/mL) can cause serious intestinal infection and therefore, its detection in this range is critical. The proposed sensor demonstrates a linearity range from 1 to 10 9  CFU/mL with a detection time of 5 min and a limit of detection (LoD) of 1.56 CFU/mL. The proposed sensing methodology can be a potential alternative to the commercially existing ones in the near future.