Thermal aging phenomena in chitosan-related pharmaceutical systems

Results are presented of detection of thermal aging in the chitosan/ketoprofen acid (KTA) system, using low-frequency dielectric spectroscopy. Aging leads to substantial changes of the low frequency dielectric properties of the system. In order to identify the reasons for the detected aging, near in...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on dielectrics and electrical insulation 2001-06, Vol.8 (3), p.555-558
Main Authors: Bak, G.W., Bodek, K.H., Hilczer, B., Pawlowski, T.
Format: Article
Language:English
Subjects:
Aging
Cationic
Charge transfer
Chemicals
Chemistry
Chitosan
Dielectric measurements
Dielectrics
Digestive system
Drugs
Electrical insulation
Electrochemical impedance spectroscopy
Low frequencies
Moisture content
Molecular weight
Pharmaceuticals
Physics
Polymers
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Results are presented of detection of thermal aging in the chitosan/ketoprofen acid (KTA) system, using low-frequency dielectric spectroscopy. Aging leads to substantial changes of the low frequency dielectric properties of the system. In order to identify the reasons for the detected aging, near infra-red (NIR) Raman spectra and distribution of molecular weights as well as direct measurements of water content were carried out. The additional measurements suggest that water desorption is mainly responsible for the detected aging phenomena. Formation of a charge transfer complex between the anionic carbonyl group of KTA and the cationic NH3/sup +/ group of chitosan, has also been detected.
ISSN:1070-9878
1558-4135
DOI:10.1109/94.933383