New Insights Into Non-Invasive His Bundle Potential Detection on High Resolution Body Surface Recordings

• Main Authors: Tan, Nolwenn, Tixier, Romain, Duchateau, Josselin, Bear, Laura, Dubois, Remi
• Format: Conference Proceeding
• Language: English
• Subjects: Cardiology; Correlation coefficient; Electric potential; Electrodes; Laplace equations; Noise measurement; Signal resolution
• ISSN: 2325-887X
• DOI: 10.22489/CinC.2020.244

This study presents a novel non-invasive method to detect His potentials from high-resolution body surface signals. 35 patients were included in this study. All patients received an invasive electrophysiological study to determine ground truth His-Ventricular (HV) intervals. Prior to these procedures, body surface potentials were recorded using 128 electrodes sampled at 2048 Hz for 8 minutes. Signal averaging was performed on the body surface signals using only the beats occurring during the exhalation phase of respiration. 4 "wide" bipolar (2 electrodes spaced 50 mm) in the vertical, horizontal, right diagonal and left diagonal directions, and 24 Laplacians signals were created and high-pass filtered at 30Hz. Noninvasive HV interval measurements were not performed on 2 (6%) patients because body surface signals were too noisy. His potentials were invisible on the bipolar signals for 5 (14%) patients and on the Laplacian signals for 7 patients (20%). Comparison between invasive (58.5±15ms) and non-invasive HV interval (53.6±14ms) measured with bipolar signals, revealed a squared correlation coefficient (SCC) of 0.66. HV intervals measured with Laplacian signals were less correlated (53.8±18ms) with a SCC of 0.50. This study shows promising results that HV interval can be measured non-invasively using bipolar and Laplacians signals.