Neuro-electronic devices and nanotools to interact with neuronal networks

Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanoto...

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Bibliographic Details
Main Authors: Martinoia, S., Andolfi, A., Muzzi, L., Pisano, M., Spanu, A., Raiteri, R.
Format: Conference Proceeding
Language:English
Subjects:
Biological neural networks
In vitro
Nanoscale devices
Neural activity
Semiconductor device modeling
Three-dimensional displays
Two dimensional displays
Online Access:Request full text
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Summary:Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanotools to characterize the (patho)physiology of such in vitro complex systems. Large-scale CMOS micro-transducer arrays, coupled to 2D and 3D networks are presented together with new techniques for non-invasively modulate the cell activity. Specifically, piezo-electric nano particles and gold nano rods are used to excite-inhibit the neural activity that is recorded by the micro-transducer arrays. Concept, technology, and preliminary results are presented toward the implementation of a bio-hybrid brain-on-a-chip.
ISSN:2156-017X
DOI:10.1109/IEDM13553.2020.9372044