Microwave Sensor Dedicated to the Determination of the Dielectric Properties of 3D Biological Models from 500MHz to 20GHz

Biologists introduced some years ago an intermediate biological model between 2D cell culture and 3D in vivo tissues, called microtissues or spheroids. To study such 3D models, techniques are currently applied, including electromagnetic waves-based methods at low frequencies. This frequency range do...

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Bibliographic Details
Main Authors: Peytral-Rieu, Olivia, Grenier, Katia, Dubuc, David
Format: Conference Proceeding
Language:English
Subjects:
biological spheroids
Biological system modeling
Dielectric measurement
In vivo
microtechnology
microtissue
microwave biosensor
Microwave sensors
Microwave theory and techniques
Solid modeling
Three-dimensional displays
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Summary:Biologists introduced some years ago an intermediate biological model between 2D cell culture and 3D in vivo tissues, called microtissues or spheroids. To study such 3D models, techniques are currently applied, including electromagnetic waves-based methods at low frequencies. This frequency range does not allow the penetration of the waves inside the cells, conversely to the microwaves. There is consequently a strong interest to develop an appropriate microwave-based sensor dedicated to microtissues analysis. This constitutes the topic of this paper with the introduction of a new microwave sensor, suitable for the dielectric characterization of microtissues. An analytic method is proposed to extract their electrical parameters. The evaluation of the biosensor is performed, while measuring large polystyrene beads with known dielectric properties, followed then by the dielectric evaluation of fixed spheroids from 500MHz to 20GHz.
ISSN:2576-7216
DOI:10.1109/IMS19712.2021.9574794