AI-Enabled High-Throughput Wireless Telemetry for Effective Photodynamic Therapy

Photodynamic therapy (PDT) is an alternative method for treating cancer, and its outcomes are highly dependent on effective light delivery to tumor cells to activate a photosensitizer. Existing approaches paired with advances in wireless technologies enable remote delivery of light to tumors in a fr...

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Bibliographic Details
Main Authors: Kim, Woo Seok, Woo, Hyun-Myung, Khot, M. Ibrahim, Hong, Sungcheol, Jayne, David G., Yoon, Byung-Jun, Park, Sung Il
Format: Conference Proceeding
Language:English
Subjects:
AI (artificial intelligence)
Animals
customized DeepLabCut (DLC)
Handheld computers
Implants
Medical treatment
photodynamic therapy (PDT)
Power transmission
Transmitting antennas
Wireless communication
wireless optoelectronic implants
wireless telemetry
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Summary:Photodynamic therapy (PDT) is an alternative method for treating cancer, and its outcomes are highly dependent on effective light delivery to tumor cells to activate a photosensitizer. Existing approaches paired with advances in wireless technologies enable remote delivery of light to tumors in a freely behaving animal, but its efficacy is limited by wireless coverage of a power transmission system. Here, we introduce AI-informed low-power wireless telemetry that allows for real-time pose-estimation of multiple animals in a cage to enable adaptive control of transmission coil antennas. This results in significantly improved wireless coverage and thereby robust activation of the implanted devices (in up to 5 animals) in a cage. Hypericin mediated PDT demonstrated substantial suppression of tumor growth in a high-throughput manner, suggesting that the proposed platform provides the potential for widespread use in fundamental research, and ultimately, in clinical settings.
ISSN:2576-2303
DOI:10.1109/IEEECONF53345.2021.9723372