Comprehensive Evaluation of Magnetic Particle Imaging (MPI) Scanners for Biomedical Applications

Magnetic particle imaging (MPI) is an emerging tomographic imaging technique that tracks and quantitatively measures the spatial distribution of the superparamagnetic iron oxide nanoparticles (SPIONs). It is a radiation-free, background-free, and signal attenuation-free imaging modality that utilize...

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Bibliographic Details
Published in:IEEE access 2022, Vol.10, p.86718-86732
Main Authors: Irfan, Muhammad, Dogan, Nurcan
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Computed tomography
Computed tomography (CT)
Image reconstruction
Imaging
Imaging techniques
Iron
Iron oxides
Magnetic cores
Magnetic fields
Magnetic particle imaging
magnetic particle imaging (MPI)
Magnetic resonance imaging
magnetic resonance imaging (MRI)
Medical imaging
Nanoparticles
Performance evaluation
Positron emission
Positron emission tomography
positron emission tomography (PET)
Scanners
Signal generation
Spatial distribution
Spatial resolution
superparamagnetic iron oxide nanoparticles (SPIONs)
Tomography
Toxicity
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Summary:Magnetic particle imaging (MPI) is an emerging tomographic imaging technique that tracks and quantitatively measures the spatial distribution of the superparamagnetic iron oxide nanoparticles (SPIONs). It is a radiation-free, background-free, and signal attenuation-free imaging modality that utilizes the non-linear behavior of the tracer agents. The minimum acquisition time, high spatial resolution, and extreme sensitivity make it ideal for medical imaging in comparison to magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). SPIONs are the main source of signal generation and have a significant influence on MPI scanner characteristics. Many research groups in the world are working to produce optimal tracer agents with a low toxicity profile for MPI applications. Versatile MPI scanners are developed and implemented at the pre-clinical stage to evaluate the performance of the system parameters. This review aims at giving an overview of the current developments and significant achievements of the tracer agents, imager design, image reconstruction, and potential applications of MPI scanners since their first exposure to the scientific world in 2005.
ISSN:2169-3536
2169-3536
DOI:10.1109/ACCESS.2022.3197586