In Situ Detection of Gastrointestinal Inflammatory Biomarkers Using Electrochemical Gas Sensors

More than two decades ago it was discovered that nitric oxide (NO) concentrations in gas aspirated during colonoscopy were more than 100 times higher in patients diagnosed with Ulcerative Colitis (UC) than controls. While this provides a diagnostic opportunity, it has not been possible to perform in...

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Bibliographic Details
Main Authors: Huang, Hen-Wei, Ehmke, Claas, Steiger, Christoph, Ballinger, Ian, Jimenez, Miguel, Phan, Nhi, Sun, Haoying, Ishida, Keiko, Kuosmanen, Johannes, Jenkins, Josh, Korzenik, Joshua, Hayward, Alison, Traverso, Giovanni
Format: Conference Proceeding
Language:English
Subjects:
Animals
Biological system modeling
Biomarkers
Colonoscopy
Gastrointestinal tract
In vivo
Intestines
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Summary:More than two decades ago it was discovered that nitric oxide (NO) concentrations in gas aspirated during colonoscopy were more than 100 times higher in patients diagnosed with Ulcerative Colitis (UC) than controls. While this provides a diagnostic opportunity, it has not been possible to perform in situ detection of NO via a non-invasive manner. This work presents the feasibility of in situ detection of NO by means of a capsule-like electrochemical gas sensor. Our in vivo results in a large animal model of intestinal inflammation show that NO can be directly detected at the site of inflammation and that it quickly dissipates to surrounding tissues, demonstrating the importance of in situ detection.
ISSN:2694-0604
DOI:10.1109/EMBC48229.2022.9871468