An ultrathin low-invasive flexible probe for accurate neural stimulating

Neural probe plays an important role in neuroscience research and neurological diseases diagnosis. The flexible neural probes made by polymer emerging in recent years have been manifested more compliant and compatible with bio-tissues. However, the implantation of the flexible probe becomes another...

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Bibliographic Details
Published in:IEEE electron device letters 2022-11, Vol.43 (11), p.1-1
Main Authors: Guo, Zhejun, Wang, Longchun, Tu, Kejun, Xi, Ye, Hong, Wen, Wang, Xiaolin, Yang, Bin, Lin, Zude, Liu, Jingquan
Format: Article
Language:English
Subjects:
accurate
Biocompatibility
Electrodes
Fabrication
Flexible
Gold
Immune system
implantable
Implantation
MEMS
neural probe
Neurological diseases
Platinum black
Polyethylene glycol
Probes
Silicon
Transient analysis
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Summary:Neural probe plays an important role in neuroscience research and neurological diseases diagnosis. The flexible neural probes made by polymer emerging in recent years have been manifested more compliant and compatible with bio-tissues. However, the implantation of the flexible probe becomes another problem to be solved. In this letter, we propose a platinum black (Ptb) enhanced ultrathin flexible neural probe for accurate implantation. Benefiting from the anchoring structure on the flexible probe and the probe coupling with the shuttle by polyethylene glycol (PEG), reliable high-precision implantation has been demonstrated in agar model. Compared with traditional probe made with stiff shank, this flexible probe with anchoring structure is biocompatible and shows less immune reaction. In addition, the population spike (PS) was evoked successfully by biphasic stimulation in vivo.
ISSN:0741-3106
1558-0563
DOI:10.1109/LED.2022.3207051