Correlation of Polyomaviruses (PyV) Infection with The Incidence of Breast Cancer in Iraqi Women

• Main Authors: Sahibsharrif, Harithabdual, Almohsen, Mustafa Ali Kayem, Al-Husseini, Yaqeen, AL-Erjan, Amran M.
• Format: Conference Proceeding
• Language: English
• Subjects: Breast carcinoma; Breast tissue; Correlation; DNA; Immunohistochemistry; Lung cancer; Manifolds; Polyomavirus (PyV); Real-Time res; Rodents; Sociology
• ISSN: 2770-7962
• DOI: 10.1109/ISMSIT56059.2022.9932818

Breast cancer is the most prevalent kind of malignancy among females all over the world, accounting for around one in every eight cases. Breast cancer is the second most prevalent malignancy in women under the age of 35, after lung cancer. Breast cancer is a type of cancer that arises from breast tissue. It is characterized by the uncontrolled development of abnormal cells in the milk-producing glands of the breast or in the passageways that transport milk to the nipples of the breast. Polyomavirus (PyV) infections were accidentally exposed in the 1950s when characterizing a infectious agent causing manifold tumors within rodents. The purpose of this study was to detect the prevalence of(PyV) in breast cancer. A total 100 breast tissue samples of female patients were included in this study, 80 samples with breast cancer and 20 samples of normal breast tissue were considered as control group involved in this study. Ages of patients ranges from 20 to 69 years, Real-Time PCR was performed to detect(PyV) DNA among breast tissue, andImmunohistochemistry was performed for detection of (ER, PR and Her2). The Real-Time PCR detection rate of (PyV) was reported in 13 out of 80 cases of breast carcinoma represented (16%) with no significant difference among tissue types (P