Protein Unfolding with MoS2/SnS2 Heterostructure

In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved...

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Bibliographic Details
Main Authors: Yuan, Runyi, Si, Wei
Format: Conference Proceeding
Language:English
Subjects:
heterostructure
Nanobioscience
Nanoscale devices
Peptides
protein sequencing
protein unfolding
Proteins
Sequential analysis
Surgery
Targeted drug delivery
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Summary:In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved problems the unfolding of structured proteins into chain-like structures is a prerequisite for nanopore sequencing. In this work, we propose a general two-dimensional heterostructure that can be used for protein unfolding without the need for specific biological or chemical reagents. The role of two-dimensional heterostructures on protein unfolding is studied by molecular dynamics, which provides new inspiration for the subsequent experiments to achieve a general and reliable protein unfolding method.
ISSN:2694-510X
DOI:10.1109/3M-NANO56083.2022.9941518