Accessing random diffusivity in a hydrogel-based brain's paranchyma phantom

Recently, there is evidence that processes of metabolite transport extracellular (interstitial) space of the brain's parenhyma has great importance for the controlling neuronal activity, regulation of the sleep/wake cycle, clearance of waste metabolites, etc. At the same time, quantification of...

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Bibliographic Details
Main Authors: Lavrova, Anastasia I., Sychev, Alexander V., Vanina, Anastasia S., Grekhnyova, Elena V., Postnikov, Eugene B.
Format: Conference Proceeding
Language:English
Subjects:
Brain parenhyma
diffusion processes
dynamics of markers'transport
Fluorescence
hydrogels
Image processing
Phantoms
Process control
Recording
Regulation
Shape
wave propagation
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Summary:Recently, there is evidence that processes of metabolite transport extracellular (interstitial) space of the brain's parenhyma has great importance for the controlling neuronal activity, regulation of the sleep/wake cycle, clearance of waste metabolites, etc. At the same time, quantification of the respective transport processes is a complicated still unsolved task. In this work, we report a set of methods based on the image processing of recordings of the fluorescence marker spread in a hydrogel-based phantom, which sufficiently accurately mimic the properties of the brain's parenchyma as a microstructured medium with randomly distributed local diffusivity.
ISSN:2189-8723
DOI:10.1109/ICIIBMS55689.2022.9971620