The effect of parameter uncertainty on a novel insulin bolus calculator

A simple control law is derived from the eponymous Bergman Minimal Model with the aim of implementing patient specific insulin injections. The Fisher Information Matrix is used to form an approximate necessary condition for the a posteriori identifiability of the Bergman Minimal Model's paramet...

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Bibliographic Details
Main Authors: Palma, R, Edgar, T.F
Format: Conference Proceeding
Language:English
Subjects:
Algebra
Biological and medical control systems
Other topics in statistics
Online Access:Get full text
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Summary:A simple control law is derived from the eponymous Bergman Minimal Model with the aim of implementing patient specific insulin injections. The Fisher Information Matrix is used to form an approximate necessary condition for the a posteriori identifiability of the Bergman Minimal Model's parameters from home-use continuous glucose measurements. It is shown that despite parameter uncertainty control moves based on the control law are not subject to physiologically significant variability.
DOI:10.1049/ic.2010.0387