Spectrophotometric Estimation of Faropenem in bulk and in Pharmaceutical Formulations

A simple, economical, precise, reliable and reproducible Visible Spectrophotometric Method has been developed for the estimation of Faropenem in bulk as well as in tablet formulations. The method is based on the formation of blue colored chromogen, when the drug reacts with Folin-Ciocalteu (F-C) rea...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2013-04, Vol.6 (4), p.363-365
Main Authors: Jyothsna, D, Prakash, K. Vanitha, Dacha, Anusha, Ameena, Sabahath, Riaz, Shaik
Format: Article
Language:English
Subjects:
absorption spectrum
calibration curve
Faropenem
FC(folin-ciocalteu) reagent
Ultraviolet-Visible double beam-spectrophotometer
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Summary:A simple, economical, precise, reliable and reproducible Visible Spectrophotometric Method has been developed for the estimation of Faropenem in bulk as well as in tablet formulations. The method is based on the formation of blue colored chromogen, when the drug reacts with Folin-Ciocalteu (F-C) reagent in alkaline medium. The colored species has an absorption maximum at 745 nm and obeys Beer's law in the concentration range 50–300 mcg/mL. The apparent molar absorptivity and sandell's sensitivity were 0.370x 103 and 0.587 respectively. The slope and intercept of the equation of the regression line are 0.001 and 0.0479 respectively. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Faropenem in pharmaceutical formulations.
ISSN:0974-3618
0974-360X