Fate of Newly Formed Periglomerular Cells in the Olfactory Bulb

It is well established that olfactory receptor cells are replaced during life. Periglomerular (PG) cells of the olfactory bulb have recently been demonstrated to be produced following proliferation and migration of periventricular neuronal precursor cells even in adulthood. The purpose of the presen...

Full description

Saved in:
Bibliographic Details
Published in:Acta oto-laryngologica 2000, Vol.120 (7), p.876-879
Main Authors: KATO, T, YOKOUCHI, K, KAWAGISHI, K, FUKUSHIMA, N, MIWA, T, MORIIZUMI, T
Format: Article
Language:English
Subjects:
Adult Neurogenesis Cell Death Migration Olfactory Glomerular Layer
Animals
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Olfactory Bulb - cytology
Olfactory system and olfaction. Gustatory system and gustation
Rats
Rats, Wistar
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is well established that olfactory receptor cells are replaced during life. Periglomerular (PG) cells of the olfactory bulb have recently been demonstrated to be produced following proliferation and migration of periventricular neuronal precursor cells even in adulthood. The purpose of the present study was to examine the fate of newly formed PG cells in adult rodents. Using 5-bromodeoxyuridine (BrdU), we carried out a quantitative immunohistochemical analysis of BrdU-positive cells in the bulbar glomerular layer at different survival periods. Each number of BrdU-positive PG cells per 100 olfactory glomeruli was 34.1 +/- 3.3 (1 week), 57.2 +/- 2.7 (2 weeks), 28.0 +/- 4.7 (4 weeks) and 25.9 +/- 1.6 (8 weeks). These results indicate that bulbar PG cells, similar to olfactory receptor cells, are mostly replaced during life, and that the olfactory system is composed of disposable neuronal networks centrally as well as peripherally.
ISSN:0001-6489
1651-2251
DOI:10.1080/000164800750061769