Effects of Impulse Noise on Cortical Response Threshold and Inner Ear Activity of Succinic Dehydrogenase and Acetylcholinesterase in Guinea Pigs

The effects of impulse noise (firecrackers at 170 dB SPL, 1, 10, 20 rounds) on auditory cortical response threshold (CRT) and activity of succinic dehydrogenase (SDH) and acetylcholinesterase (AchE) in the inner ear were studied in 37 guinea pigs. The results showed that extent of damage in the coch...

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Bibliographic Details
Published in:Acta oto-laryngologica 1998, Vol.118 (6), p.813-816
Main Author: Suoqiang Zhai, Sichang Jiang, Rui Gu, Weiyang Yang, Peiying Wang
Format: Article
Language:English
Subjects:
Acetylcholinesterase - analysis
Animals
Auditory Cortex - physiology
Auditory Threshold - physiology
Biological and medical sciences
Cochlea - enzymology
Cochlea - injuries
Cochlea - physiopathology
Coloring Agents
Ent. Stomatology
Environmental Exposure
Follow-Up Studies
Guinea Pigs
Hair Cells, Auditory, Inner - enzymology
Hair Cells, Auditory, Inner - ultrastructure
Hair Cells, Auditory, Outer - enzymology
Hair Cells, Auditory, Outer - ultrastructure
Hearing - physiology
Hearing Disorders - enzymology
Hearing Disorders - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nerve Endings - enzymology
Nerve Endings - ultrastructure
Noise - adverse effects
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Random Allocation
Recovery of Function
Succinate Dehydrogenase - analysis
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Summary:The effects of impulse noise (firecrackers at 170 dB SPL, 1, 10, 20 rounds) on auditory cortical response threshold (CRT) and activity of succinic dehydrogenase (SDH) and acetylcholinesterase (AchE) in the inner ear were studied in 37 guinea pigs. The results showed that extent of damage in the cochlea was related to amount of exposure to the noise. Exposure to 10 rounds resulted in temporal threshold shift (TTS); to 20 rounds the result was permanent threshold shift (PTS). For the period when TTS existed, inverse correlation was noticed between enzyme activity change and CRT shift. The correlation could not be established when PTS was induced. The results suggest that the pathomechanism of PTS was more complex than that of TTS. The significance of the results is discussed.
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489850182495